Respiratory weakness is associated with limb weakness and delayed weaning in critical illness*

@article{deJonghe2007RespiratoryWI,
  title={Respiratory weakness is associated with limb weakness and delayed weaning in critical illness*},
  author={Bernard de Jonghe and Sylvie Bastuji‐Garin and M. C. Durand and Isabelle Malissin and Pablo Duarte Rodrigues and Charles Cerf and Herv{\'e} Outin and Tarek Sharshar},
  journal={Critical Care Medicine},
  year={2007},
  volume={35},
  pages={2007-2015}
}
Objective:Although critical illness neuromyopathy might interfere with weaning from mechanical ventilation, its respiratory component has not been investigated. We designed a study to assess the level of respiratory muscle weakness emerging during the intensive care unit stay in mechanically ventilated patients and to examine the correlation between respiratory and limb muscle strength and the specific contribution of respiratory weakness to delayed weaning. Design:Prospective observational… 
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427 Citations
Highly Influential Citations
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Background Citations
106
Methods Citations
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Results Citations
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427 Citations

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Citation Type

Coexistence and Impact of Limb Muscle and Diaphragm Weakness at Time of Liberation from Mechanical Ventilation in Medical Intensive Care Unit Patients
TLDR
Diaphragm dysfunction is twice as frequent as limb muscle weakness and has a direct negative impact on weaning outcome, and limb muscle Weakness was associated with longer duration of MV and hospital stay and the two types of muscle weakness have only limited overlap.
The Critical Illness Polyneuropathy in Septic Patients With Prolonged Weaning From Mechanical Ventilation: Is the Diaphragm Also Affected? A Pilot Study
TLDR
The pilot findings suggested that CRIMYNE is common in septic patients with prolonged weaning from MV (MV ≥ 14 d), and the inability to move limbs against gravity is frequently associated with peripheral and diaphragmatic CRIMyNE, and the findings of CR IMYNE in peripheral electrophysiological tests are associated with diaphagmatic involvement.
Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay. A Pilot Study.
TLDR
Long-term weakness in ICU survivors results from heterogeneous muscle pathophysiology with variable combinations of muscle atrophy and impaired contractile capacity is not explained by ongoing muscle proteolysis, inflammation, or diminished mitochondrial content.
Acquired weakness, handgrip strength, and mortality in critically ill patients.
TLDR
Handgrip strength was lower in subjects with ICUAP and had good test performance for diagnosingICUAP, and handgrip dynamometry is also independently associated with poor hospital outcome and may serve as a simple test to identify ICU AP.
Effect of electrical muscle stimulation on prevention of ICU acquired muscle weakness and facilitating weaning from mechanical ventilation
Diaphragm Dysfunction and weaning in patients with Intensive Care Unit Acquired Weakness
TLDR
Eighty% of the ICUAW patient had a diaphragm dysfunction but 50% were successfully extubated and no statistical links were found betweenICUAW and DD.
Recovery from ICU-acquired weakness; do not forget the respiratory muscles!
TLDR
The focus of rehabilitation in patients who are critically ill is on the prevention and treatment of ICUAW, oftentimes specifically targeting lower limb muscle function.
ResearchIncreased duration of mechanical ventilation is associated with decreased diaphragmatic force : a prospective observational study
TLDR
Duration of mechanical ventilation is associated with a logarithmic decline in diaphragmatic force, which is compatible with the concept of VIDD, and is necessary in particular situations, such as during the use of neuromuscular blockade.
associated with decreased diaphragmatic force: a prospective observational study
TLDR
Duration of mechanical ventilation is associated with a logarithmic decline in diaphragmatic force, which is compatible with the concept of VIDD, and may be due to other potentially contributing factors such as sedatives/analgesics, sepsis, or others.
Muscle weakness in septic patients requiring mechanical ventilation: protective effect of transcutaneous neuromuscular electrical stimulation.
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