Respiratory tract lesions induced by sensory irritants at the RD50 concentration.

@article{Buckley1984RespiratoryTL,
  title={Respiratory tract lesions induced by sensory irritants at the RD50 concentration.},
  author={Louise A. Buckley and Xiaohua Jiang and Robert Andrew James and Kevin T. Morgan and Craig S. Barrow},
  journal={Toxicology and applied pharmacology},
  year={1984},
  volume={74 3},
  pages={
          417-29
        }
}
Exposure of mice to airborne sensory irritants causes a concentration-dependent depression of respiratory rate. The RD50 concentration (that concentration which elicits a respiratory rate decrease of 50%) has been predicted to be an unacceptable occupational exposure concentration due to intolerable sensory irritation and possible respiratory tract injury in humans. The purpose of this study was (1) to determine whether lesions occur in the respiratory tract of Swiss-Webster mice after exposure… CONTINUE READING
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