Respiratory syncytial virus non-structural protein 1 facilitates virus replication through miR-29a-mediated inhibition of interferon-α receptor.

@article{Zhang2016RespiratorySV,
  title={Respiratory syncytial virus non-structural protein 1 facilitates virus replication through miR-29a-mediated inhibition of interferon-α receptor.},
  author={Yao Zhang and Lihua Yang and Hao Wang and Guocheng Zhang and Xin Yu Sun},
  journal={Biochemical and biophysical research communications},
  year={2016},
  volume={478 3},
  pages={1436-41}
}
Human respiratory syncytial virus (RSV) non-structural protein 1 (NS1) has recently been suggested to inhibit type-I interferon (IFN)-dependent immune responses during RSV infection. However, the precise function of RSV NS1 protein in reducing the antiviral effects of IFNs against RSV is poorly understood. The roles of cellular miRNAs in the defence against RSV infection are not well characterized. In this study, qRT-PCR analysis revealed that miR-29a expression was upregulated in the… CONTINUE READING
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