Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NF-kappaB-dependent mechanism.

@article{Lindemans2006RespiratorySV,
  title={Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NF-kappaB-dependent mechanism.},
  author={Caroline A Lindemans and Paul James Coffer and Ingrid M. M. Schellens and Patricia M A de Graaff and Jan L. L. Kimpen and Leo Koenderman},
  journal={Journal of immunology},
  year={2006},
  volume={176 9},
  pages={5529-37}
}
Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract disease in children. It is associated with increased neutrophil numbers in the airway. In this study, we assessed whether this ssRNA virus can directly influence granulocyte longevity. By culturing RSV with granulocytes, it was observed that virus delays both constitutive neutrophil and eosinophil apoptosis. Using pharmacological inhibitors, the RSV-induced delay in neutrophil apoptosis was found to be dependent on… CONTINUE READING

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