Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth muscle.

@article{Moore2006RespiratorySV,
  title={Respiratory syncytial virus infection reduces beta2-adrenergic responses in human airway smooth muscle.},
  author={Paul E Moore and Gary Cunningham and Mark M Calder and A. Dematteo and Mark E Peeples and Marshall Summar and R Stokes Peebles},
  journal={American journal of respiratory cell and molecular biology},
  year={2006},
  volume={35 5},
  pages={559-64}
}
Although respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract illness in infants, the effect of RSV on human airway smooth muscle (HASM) has not been studied. We hypothesized that RSV has direct effects on cAMP formation and beta(2)-adrenergic receptor (ADRB2) density and that ADRB2 haplotype influences this response. A recombinant green-fluorescent protein (rg) expressing RSV was used to determine whether RSV could infect cultured HASM. Influence of RSV… CONTINUE READING
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