Respiratory syncytial virus induces oxidative stress by modulating antioxidant enzymes.

@article{Hosakote2009RespiratorySV,
  title={Respiratory syncytial virus induces oxidative stress by modulating antioxidant enzymes.},
  author={Yashoda M. Hosakote and Tianshuang Liu and Shawn Monique Castro and Roberto P Garofalo and Antonella Casola},
  journal={American journal of respiratory cell and molecular biology},
  year={2009},
  volume={41 3},
  pages={348-57}
}
Oxidative stress plays an important role in the pathogenesis of lung inflammation. Respiratory syncytial virus (RSV) infection induces reactive oxygen species (ROS) production in vitro and oxidative injury in lungs in vivo; however, the mechanism of RSV-induced cellular oxidative stress has not been investigated. Therefore, we determined whether RSV infection of airway epithelial cells modified the expression and/or activities of antioxidant enzymes (AOE). A549 cells, a human alveolar type II… CONTINUE READING