Respiratory syncytial virus M2-1 protein requires phosphorylation for efficient function and binds viral RNA during infection.

@article{Cartee2001RespiratorySV,
  title={Respiratory syncytial virus M2-1 protein requires phosphorylation for efficient function and binds viral RNA during infection.},
  author={Tara L Cartee and Gail W. Wertz},
  journal={Journal of virology},
  year={2001},
  volume={75 24},
  pages={12188-97}
}
The M2-1 protein of respiratory syncytial (RS) virus is a transcriptional processivity and antitermination factor. The M2-1 protein has a Cys3His1 zinc binding motif which is essential for function, is phosphorylated, and has been shown to interact with the RS virus nucleocapsid (N) protein. In the work reported here, we determined the sites at which the M2-1 protein was phosphorylated and investigated the importance of these phosphorylated residues for M2-1 function in transcription. By… CONTINUE READING
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