Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses.

@article{Harcourt2006RespiratorySV,
  title={Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses.},
  author={Jennifer L Harcourt and Rene Alvarez and Les P. Jones and Christine A Henderson and Larry J. Anderson and Ralph A Tripp},
  journal={Journal of immunology},
  year={2006},
  volume={176 3},
  pages={1600-8}
}
Interactions between fractalkine (CX3CL1) and its receptor, CX3CR1, mediate leukocyte adhesion, activation, and trafficking. The respiratory syncytial virus (RSV) G protein has a CX3C chemokine motif that can bind CX3CR1 and modify CXCL1-mediated responses. In this study, we show that expression of the RSV G protein or the G protein CX3C motif during infection is associated with reduced CX3CR1+ T cell trafficking to the lung, reduced frequencies of RSV-specific, MHC class I-restricted IFN-gamma… CONTINUE READING

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