Respiratory syncytial virus (RSV): a scourge from infancy to old age

@article{Coultas2019RespiratorySV,
  title={Respiratory syncytial virus (RSV): a scourge from infancy to old age},
  author={James Andrew Coultas and Rosalind Smyth and Peter J. M. Openshaw},
  journal={Thorax},
  year={2019},
  volume={74},
  pages={986 - 993}
}
Respiratory syncytial virus (RSV) is the most common single cause of respiratory hospitalisation of infants and is the second largest cause of lower respiratory infection mortality worldwide. In adults, RSV is an under-recognised cause of deterioration in health, particularly in frail elderly persons. Infection rates typically rise in late autumn and early winter causing bronchiolitis in infants, common colds in adults and insidious respiratory illness in the elderly. Virus detection methods… 
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References

SHOWING 1-10 OF 118 REFERENCES
Respiratory syncytial virus infection in adults.
TLDR
Originally considered as only a paediatric pathogen, respiratory syncytial virus (RSV) has recently been shown to be a significant cause of respiratory illness among elderly and high-risk adults and vaccine against RSV remain an unachieved goal.
Respiratory syncytial virus entry and how to block it
TLDR
The recent findings that have begun to elucidate RSV entry mechanisms are summarized, progress on the development of new interventions are described and a perspective on gaps in knowledge that require further investigation is concluded.
Respiratory syncytial virus: The virus, the disease and the immune response
  • P. Ogra
  • Medicine, Biology
    Paediatric Respiratory Reviews
  • 2004
Respiratory syncytial virus infection in elderly and high-risk adults.
TLDR
RSV infection is an important illness in elderly and high-risk adults, with a disease burden similar to that of nonpandemic influenza A in a population in which the prevalence of vaccination for influenza is high.
A Role for Immune Complexes in Enhanced Respiratory Syncytial Virus Disease
TLDR
It is demonstrated that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell–deficient mice but not in controls, and correlation with the enhanced disease observed in children is shown by providing evidence of complement activation in postmortem lung sections from children with enhancedRSV disease.
Variation in Timing of Respiratory Syncytial Virus Outbreaks: Lessons From National Surveillance
TLDR
A summary and update of analyses using National Respiratory and Enteric Virus Surveillance System (NREVSS) data is provided to explore using surveillance data to better define the timing of RSV activity and RSV immune prophylaxis.
Small hydrophobic protein of respiratory syncytial virus as a novel vaccine antigen.
TLDR
Taking into account the partial immunity evoked by recurrent natural infections, it remains to be seen whether HRSV subunit vaccines solely based on the F and/or G proteins will be able to provide strong long-living immunity.
Prophylactic Administration of Respiratory Syncytial Virus Immune Globulin to High-Risk Infants and Young Children
TLDR
Immune globulin with a high titer of antibodies against respiratory syncytial virus may offer infants and young children at risk protection from this serious, common respiratory illness.
...
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3
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5
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