Respiratory responses to leukotrienes and biogenic amines in normal and hyperreactive rats.

@article{Brunet1983RespiratoryRT,
  title={Respiratory responses to leukotrienes and biogenic amines in normal and hyperreactive rats.},
  author={Guy Brunet and Hana Piechuta and Ronald Hamel and G M Holme and Anthony W. Ford-Hutchinson},
  journal={Journal of immunology},
  year={1983},
  volume={131 1},
  pages={434-8}
}
The effects of leukotriene D4, serotonin, and methacholine were studied on respiratory smooth muscle in vitro and respiratory responses in vivo in three strains of rats. These were an inbred strain of hyperresponsive rats, Sprague Dawley rats, and Fischer rats. Trachea from inbred rats responded in vitro to serotonin and methacholine but not to leukotrienes or histamine. Parenchyma from inbred rats responded to serotonin, methacholine, and leukotrienes. In vivo respiratory responses in inbred… CONTINUE READING