Respiratory-related outputs of glutamatergic, hypercapnia-responsive parabrachial neurons in mice.

@article{Yokota2015RespiratoryrelatedOO,
  title={Respiratory-related outputs of glutamatergic, hypercapnia-responsive parabrachial neurons in mice.},
  author={Shigefumi Yokota and Satvinder Kaur and Veronique G VanderHorst and Clifford B. Saper and Nancy L. Chamberlin},
  journal={The Journal of comparative neurology},
  year={2015},
  volume={523 6},
  pages={
          907-20
        }
}
In patients with obstructive sleep apnea, airway obstruction during sleep produces hypercapnia, which in turn activates respiratory muscles that pump air into the lungs (e.g., the diaphragm) and that dilate and stabilize the upper airway (e.g., the genioglossus). We hypothesized that these responses are facilitated by glutamatergic neurons in the parabrachial complex (PB) that respond to hypercapnia and project to premotor and motor neurons that innervate the diaphragm and genioglossus muscles… CONTINUE READING
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