Respiratory mutations lead to different pleiotropic effects on OXPHOS complexes in yeast and in human cells.

@article{Marsy2008RespiratoryML,
  title={Respiratory mutations lead to different pleiotropic effects on OXPHOS complexes in yeast and in human cells.},
  author={Sophie Marsy and Paule Frachon and Genevi{\`e}ve Dujardin and Anne Lombes and Claire Lemaire},
  journal={FEBS letters},
  year={2008},
  volume={582 23-24},
  pages={3489-93}
}
Pleiotropic effects in the oxidative phosphorylation pathway (OXPHOS) were investigated in yeast respiratory mutants and in cells from patients with OXPHOS genetic alterations. The main differences between yeast and human cells were (1) the site of the primary defect that was associated with pleiotropic effects, yeast complex V and human complex IV, and (2) the nature of the complex targeted by the secondary effect, yeast complex IV and human complex I. The pleiotropic effects did not correlate… CONTINUE READING

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