Respiratory mechanics and surfactant in the acute respiratory distress syndrome.

@article{Bersten1998RespiratoryMA,
  title={Respiratory mechanics and surfactant in the acute respiratory distress syndrome.},
  author={Andrew D. Bersten and Kate G Davidson and Terence E. Nicholas and Ian R. Doyle},
  journal={Clinical and experimental pharmacology & physiology},
  year={1998},
  volume={25 11},
  pages={955-63}
}
1. Although abnormalities in pulmonary surfactant were initially implicated in the pathogenesis of the acute respiratory distress syndrome (ARDS) 30 years ago, most subsequent research has focused on mediators of the parenchymal acute lung injury (ALI) and the associated increase in alveolocapillary permeability. 2. Surfactant is essential for normal breathing and the severity of ALI correlates with surfactant dysfunction and abnormalities in surfactant composition; however, no relationship has… CONTINUE READING