Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p.

  title={Respiratory-induced coenzyme Q biosynthesis is regulated by a phosphorylation cycle of Cat5p/Coq7p.},
  author={Alejandro Mart{\'i}n-Montalvo and Isabel Gonz{\'a}lez-Mariscal and Sergio Padilla and Manuel Ballesteros and David L. Brautigan and Pl{\'a}cido Navas and Carlos Santos-Oca{\~n}a},
  journal={The Biochemical journal},
  volume={440 1},
CoQ(6) (coenzyme Q(6)) biosynthesis in yeast is a well-regulated process that requires the final conversion of the late intermediate DMQ(6) (demethoxy-CoQ(6)) into CoQ(6) in order to support respiratory metabolism in yeast. The gene CAT5/COQ7 encodes the Cat5/Coq7 protein that catalyses the hydroxylation step of DMQ(6) conversion into CoQ(6). In the present study, we demonstrated that yeast Coq7 recombinant protein purified in bacteria can be phosphorylated in vitro using commercial PKA… CONTINUE READING

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Coenzyme Q--biosynthesis and functions.

Biochemical and biophysical research communications • 2010

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