Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: a comparison of endpoints.

@article{Pauluhn2002RespiratoryHT,
  title={Respiratory hypersensitivity to trimellitic anhydride in Brown Norway rats: a comparison of endpoints.},
  author={Juergen Pauluhn and Petra Eidmann and Alexius Freyberger and Grazyna Wasinska-Kempka and H Vohr},
  journal={Journal of applied toxicology : JAT},
  year={2002},
  volume={22 2},
  pages={89-97}
}
A rat bioassay has been developed to provide an objective approach for the identification and classification of respiratory allergy using trimellitic anhydride (TMA), which is a known respiratory tract irritant and asthmagen. Particular emphasis was placed on the study of route-of-induction-dependent effects and their progression upon inhalation challenge with TMA (approximately 23 mg m(-3) for a duration of 30 min), which included analysis of specific and non-specific airway hyperreactivity… CONTINUE READING

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