Respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate in guinea pigs: comparison with trimellitic anhydride.

@article{Pauluhn1999RespiratoryHT,
  title={Respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate in guinea pigs: comparison with trimellitic anhydride.},
  author={Juergen Pauluhn and Rebecca Jane Dearman and Jane Doe and Paul M Hext and Timothy D. Landry},
  journal={Inhalation toxicology},
  year={1999},
  volume={11 3},
  pages={187-214}
}
Published evidence demonstrates successful induction and elicitation of respiratory hypersensitivity in guinea pigs by the known human respiratory allergens trimellitic anhydride (TMA) and diphenylmethane-4,4'-diisocyanate (MDI). From these data it is apparent that TMA-related respiratory hyperresponsiveness can be elicited readily in guinea pigs upon inhalation challenge with the free chemical. Despite the interlaboratory variability in methodological procedures used for the sensitization as… CONTINUE READING
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delayed onset of airway hypersensitivity in guinea-pigs

  • J. Pauluhn, U. Mohr
  • J. Appl. Toxicol
  • 1994
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