Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging.

@article{Wei2009RespiratoryFD,
  title={Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression during aging.},
  author={Yau-Huei Wei and S Wu and Yi-Shing Ma and Hsin-Chen Lee},
  journal={Chang Gung medical journal},
  year={2009},
  volume={32 2},
  pages={113-32}
}
Aging is a biological process that is characterized by the gradual loss of physiological function and increases in the susceptibility to disease of an individual. During the aging process, a wide spectrum of alterations in mitochondria and mitochondrial DNA (mtDNA) has been observed in somatic tissues of humans and animals. This is associated with the decline in mitochondrial respiratory function; excess production of the reactive oxygen species (ROS); increase in the oxidative damage to mtDNA… CONTINUE READING
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