Respiratory distress and surfactant inhibition following vagotomy in rabbits.

  title={Respiratory distress and surfactant inhibition following vagotomy in rabbits.},
  author={David D Berry and Machiko Ikegami and Alan Hall Jobe},
  journal={Journal of applied physiology},
  volume={61 5},
We used the model of bilateral cervical vagotomy of adult rabbits to cause respiratory failure characterized by pulmonary edema, decreased lung compliance, and atelectasis. We documented an 18-fold increase in radiolabeled albumin leak from the vascular space into alveolar washes of vagotomy vs. sham-operated rabbits (P less than 0.01). Despite a twofold increase in percent of prelabeled saturated phosphatidylcholine secreted (P less than 0.01), the alveolar wash saturated phosphatidylcholine… CONTINUE READING


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