Respiratory depression following diazepam: reversal with high-dose naloxone.

  title={Respiratory depression following diazepam: reversal with high-dose naloxone.},
  author={C. R. Jordan and Julie Lehane and John Gwyn Jones},
  volume={53 4},
The authors compared the effects of naloxone and saline solution on the respiratory changes following diazepam in a double-blind crossover trial in six subjects. Following baseline measurements of respiration, each subject was given diazepam, 15 mg, intravenously. Sixty and ninety-five minutes later each subject received either two doses of naloxone, 15 mg, intravenously, or two doses of the equivalent volume of saline solution. Forty-five minutes after diazepam administration the slopes of the… CONTINUE READING

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