Respiratory control and sternohyoid muscle structure and function in aged male rats: Decreased susceptibility to chronic intermittent hypoxia

@article{Skelly2012RespiratoryCA,
  title={Respiratory control and sternohyoid muscle structure and function in aged male rats: Decreased susceptibility to chronic intermittent hypoxia},
  author={J Richard Skelly and Deirdre Edge and Christine M Shortt and James F. X. Jones and Ken D. O’Halloran},
  journal={Respiratory Physiology & Neurobiology},
  year={2012},
  volume={180},
  pages={175-182}
}
Obstructive sleep apnoea syndrome (OSAS) is a common respiratory disorder characterized by chronic intermittent hypoxia (CIH). We have shown that CIH causes upper airway muscle dysfunction in the rat due to oxidative stress. Ageing is an independent risk factor for the development of OSAS perhaps due to respiratory muscle remodelling and increased susceptibility to hypoxia. We sought to examine the effects of CIH on breathing and pharyngeal dilator muscle structure and function in aged rats… CONTINUE READING

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