Respiratory complex I: 'steam engine' of the cell?

  title={Respiratory complex I: 'steam engine' of the cell?},
  author={Rouslan Efremov and Leonid A. Sazanov},
  journal={Current opinion in structural biology},
  volume={21 4},
Complex I is the first enzyme of the respiratory chain and plays a central role in cellular energy production. It has been implicated in many human neurodegenerative diseases, as well as in ageing. One of the biggest membrane protein complexes, it is an L-shaped assembly consisting of hydrophilic and membrane domains. Previously, we have determined structures of the hydrophilic domain in several redox states. Last year was marked by fascinating breakthroughs in the understanding of the complete… CONTINUE READING
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