Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments.

Abstract

The mitochondrial respiratory chain (RC) produces most of the cellular ATP and requires strict quality-control mechanisms. To examine RC subunit proteostasis in vivo, we measured RC protein half-lives (HLs) in mice by liquid chromatography-tandem mass spectrometry with metabolic [(2)H3]-leucine heavy isotope labeling under divergent conditions. We studied 7… (More)
DOI: 10.1096/fj.15-272666

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@article{Karunadharma2015RespiratoryCP, title={Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments.}, author={Pabalu P. Karunadharma and Nathan B Basisty and Ying Ann Chiao and Dao-Fu Dai and R. Paul Drake and Nick Levy and William Jen Hoe Koh and Mary J. Emond and Shane Kruse and David J. Marcinek and Michael J. MacCoss and Peter Rabinovitch}, journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology}, year={2015}, volume={29 8}, pages={3582-92} }