Respiratory Syncytial Virus Inhibits Ciliagenesis in Differentiated Normal Human Bronchial Epithelial Cells: Effectiveness of N-Acetylcysteine

@inproceedings{Mata2012RespiratorySV,
  title={Respiratory Syncytial Virus Inhibits Ciliagenesis in Differentiated Normal Human Bronchial Epithelial Cells: Effectiveness of N-Acetylcysteine},
  author={Manuel Mata and Irene Sarri{\'o}n and Miguel Armengot and C. Carda and Isidoro Mart{\'i}nez and Jos{\'e} A Melero and Julio Cortijo},
  booktitle={PloS one},
  year={2012}
}
Persistent respiratory syncytial virus (RSV) infections have been associated with the exacerbation of chronic inflammatory diseases, including chronic obstructive pulmonary disease (COPD). This virus infects the respiratory epithelium, leading to chronic inflammation, and induces the release of mucins and the loss of cilia activity, two factors that determine mucus clearance and the increase in sputum volume. These alterations involve reactive oxygen species-dependent mechanisms. The… CONTINUE READING
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