Respiratory Effects of Quazepam and Pentobarbital

@article{Murray1987RespiratoryEO,
  title={Respiratory Effects of Quazepam and Pentobarbital},
  author={A Murray and J. W. Bellville and W. H. Comer and Leslie A Danielson},
  journal={The Journal of Clinical Pharmacology},
  year={1987},
  volume={27}
}
Quazepam is a new benzodiazepine that may provide good hypnotic action with negligible effect on motor coordination or respiration. Sleep laboratory studies on human volunteers have shown quazepam 15 mg to be an effective hypnotic dose, with the 30‐mg dose being optimal. At these doses, there was no deterioration of motor performance, and the drug, when given nightly for two weeks, continued to exert hypnotic effects without serious adverse effects. Therefore, this study was designed to compare… 
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References

SHOWING 1-8 OF 8 REFERENCES
Central nervous system and cardiovascular effects of lorazepam in man
TLDR
The sedative‐hypnotic activity of single oral doses of lorazepam, a new member of the benzodiazepine series, acted indirectly on vasomotor reflexes by way of the central nervous system and about two thirds of the doses were recovered in urine as glucuronide within 96 hours.
Antagonism by caffeine of the respiratory effects of codeine and morphine.
A double-blind factorial study has been carried out to determine the respiratory effects of morphine, codeine, caffeine and combinations of caffeine and these narcotics in terms of the alveolar
The sedative-hypnotic properties of quazepam, a new hypnotic agent.
TLDR
In conscious, unrestrained squirrel monkeys and cats, quazepam produced sedation with less ataxia and less evidence of CNS stimulant action than flurazepAM, which should be an effective hypnotic with less potential for ataxIA, paradoxical excitation, and tolerance than florinol.
The respiratory effects of hydroxyzine, diazepam and pentazocine in man
TLDR
A crossover study to define precisely the relative potency of hydroxyzine in comparison with diazepam and Pentazocine was conducted.
Respiratory effects of lorazepam, pentobarbital, and pentazocine.
The respiratory effects of a new benzodiazepine, lorazepam, were compared to those of pentobarbital and pentazocine. Pentobarbital, 50 and 150 mg, produced respiratory depression, as did pentazocine,
Respiratory effects of lorazepam, pentobarbital, and pentazocine
The respiratory effects of a new benzodiarepine, lorazepam, were compared to those of pentobarbital and pentazocine. Pentobarbital, 50 and 150 mg, produced respiratory depression, as did pentazocine,