Respiratory, ionic, and functional effects of succinate esters in pancreatic islets.

Abstract

The methyl esters of succinic acid were introduced a few years ago as new potent insulin secretagogues. In the present study, they were found to increase O2 uptake by rat islets incubated in the absence or presence of D-glucose; to decrease 86Rb outflow from prelabeled islets; to stimulate biosynthetic activity in the islets, with a preferential effect on… (More)

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Cite this paper

@article{Malaisse1993RespiratoryIA, title={Respiratory, ionic, and functional effects of succinate esters in pancreatic islets.}, author={Willy Jean Malaisse and Joanne Rasschaert and Mar{\'i}a Luisa Villanueva-Pe{\~n}acarrillo and Irene Valverde}, journal={The American journal of physiology}, year={1993}, volume={264 3 Pt 1}, pages={E428-33} }