Respiration effect of synthetic progestin in small doses in normal men.

@article{Mikami1989RespirationEO,
  title={Respiration effect of synthetic progestin in small doses in normal men.},
  author={Masaki Mikami and Koichiro Tatsumi and Hiroshi Kimura and Yoshikazu Honda and Takayuki Kuriyama},
  journal={Chest},
  year={1989},
  volume={96 5},
  pages={1073-5}
}
Twelve healthy men were studied to determine the effect of ventilatory stimulation with chlormadinone acetate (CMA), a potent synthetic progesterone, in small doses (5 mg/day), on arterial blood gas levels. Using a randomized, double-blind, crossover trial, one week of CMA administration caused a significant reduction in arterial CO2 tension (PaCO2) by 4.1 +/- 2.9 (SD) mm Hg. The magnitude of the fall in PaCO2 was about the same as that obtained with dose of 50 mg per day in our previous study… CONTINUE READING