Respiration-dependent removal of exogenous H2O2 in brain mitochondria: inhibition by Ca2+.

@article{Zoccarato2004RespirationdependentRO,
  title={Respiration-dependent removal of exogenous H2O2 in brain mitochondria: inhibition by Ca2+.},
  author={Franco Zoccarato and Lucia Cavallini and Adolfo Alexandre},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 6},
  pages={4166-74}
}
In brain mitochondria, state 4 respiration supported by the NAD-linked substrates glutamate/malate in the presence of EGTA promotes a high rate of exogenous H2O2 removal. Omitting EGTA decreases the H2O2 removal rate by almost 80%. The decrease depends on the influx of contaminating Ca2+, being prevented by the Ca2+ uniporter inhibitor ruthenium red. Arsenite is also an inhibitor (maximal effect approximately 40%, IC50, 12 microm). The H2O2 removal rate (EGTA present) is decreased by 20% during… CONTINUE READING

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