Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system.

  title={Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system.},
  author={Derek A. Drechsel and Manisha B. Patel},
  journal={The Journal of biological chemistry},
  volume={285 36},
Mitochondrial reactive oxygen species (ROS) play an important role in both physiological cell signaling processes and numerous pathological states, including neurodegenerative disorders such as Parkinson disease. While mitochondria are considered the major cellular source of ROS, their role in ROS removal remains largely unknown. Using polarographic methods for real-time detection of steady-state H(2)O(2) levels, we were able to quantitatively measure the contributions of potential systems… CONTINUE READING
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