Respirable microspheres for inhalation: the potential of manipulating pulmonary disposition for improved therapeutic efficacy.

@article{Sakagami2005RespirableMF,
  title={Respirable microspheres for inhalation: the potential of manipulating pulmonary disposition for improved therapeutic efficacy.},
  author={Masahiro Sakagami and Peter R. Byron},
  journal={Clinical pharmacokinetics},
  year={2005},
  volume={44 3},
  pages={263-77}
}
Several particle engineering technologies have recently emerged, which have enabled inhaled microspheres to seek to manipulate pulmonary biopharmaceuticals, and to improve therapeutic efficacy for both local and systemic treatments. These microspheres may be designed to sustain drug release, to prolong lung retention, to achieve drug targeting and/or to enhance drug absorption and thereby, to seek the potentials of reducing dosing frequency and/or drug dose, while maintaining therapeutic… CONTINUE READING
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