Resource Co-regulation proteomics reveals substrates and mechanisms of APC / C-dependent degradation

@inproceedings{Singh2014ResourceCP,
  title={Resource Co-regulation proteomics reveals substrates and mechanisms of APC / C-dependent degradation},
  author={Sasha Anna Singh and Dominic Winter and Marc Kirchner and Ruchi Chauhan and Saima Ahmed and Nurhan Ozlu and Amit Tzur and Judith A.J. Steen and Hanno Steen},
  year={2014}
}
Using multiplexed quantitative proteomics, we analyzed cell cycledependent changes of the human proteome. We identified >4,400 proteins, each with a six-point abundance profile across the cell cycle. Hypothesizing that proteins with similar abundance profiles are co-regulated, we clustered the proteins with abundance profiles most similar to known Anaphase… CONTINUE READING