Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes.

Abstract

The contribution of remodeling-based bone formation coupled to osteoclast activity versus modeling-based bone formation that occurs independently of resorption, to the anabolic effect of PTH remains unclear. We addressed this question using transgenic mice with activated PTH receptor signaling in osteocytes that exhibit increased bone mass and remodeling… (More)
DOI: 10.1074/jbc.M113.485938

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