Resonant Formation of Strand Breaks in Sensitized Oligonucleotides Induced by Low-Energy Electrons (0.5-9 eV).

Abstract

Halogenated nucleobases are used as radiosensitizers in cancer radiation therapy, enhancing the reactivity of DNA to secondary low-energy electrons (LEEs). LEEs induce DNA strand breaks at specific energies (resonances) by dissociative electron attachment (DEA). Although halogenated nucleobases show intense DEA resonances at various electron energies in the… (More)
DOI: 10.1002/anie.201705504

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Cite this paper

@article{Schrmann2017ResonantFO, title={Resonant Formation of Strand Breaks in Sensitized Oligonucleotides Induced by Low-Energy Electrons (0.5-9 eV).}, author={Robin Sch{\"{u}rmann and Thupten Tsering and Katrin Tanzer and Stephan Denifl and Satish K V Kumar and Ilko Bald}, journal={Angewandte Chemie}, year={2017}, volume={56 36}, pages={10952-10955} }