Resonance Raman observation of the structural dynamics of FixL on signal transduction and ligand discrimination.

FixL is a heme-based O2 sensor protein, which responds to low O2 concentrations by activating the transcriptional activator FixJ. Signal transduction is initiated by the dissociation of O2 from the sensor domain of FixL, resulting in protein conformational changes that are transmitted to a histidine kinase domain. To gain insight into the FixL sensing… CONTINUE READING