Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis.

@article{Serhan2004ResolvinsDA,
  title={Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis.},
  author={Charles N Serhan and Katherine Gotlinger and Song Iee Hong and Makoto Arita},
  journal={Prostaglandins & other lipid mediators},
  year={2004},
  volume={73 3-4},
  pages={155-72}
}
The molecular basis for the beneficial impact of essential omega-3 fatty acids is of considerable interest. Recently, novel mediators generated from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that displayed potent bioactions were first identified in resolving inflammatory exudates [J. Exp. Med. 192 (2000) 1197; J. Exp. Med. 196 (2002) 1025] and in tissues enriched with DHA [J. Exp. Med. 196 (2002) 1025; J. Biol. Chem. 278 (2003) 14677]. The trivial names Resolvin (resolution… CONTINUE READING

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The compounds derived from eicosapentaenoic acid carrying potent biological actions ( i.e. , 1 - 10 nM range ) are designated E series , given their EPA precursor , and denoted as Resolvins of the E series ( Resolvin E1 or RvE1 ) , and those biosynthesized from the precursor docosahexaenoic acid are Resolvins of the D series ( Resolvin D1 or RvD1 ) .
The compounds derived from eicosapentaenoic acid carrying potent biological actions ( i.e. , 1 - 10 nM range ) are designated E series , given their EPA precursor , and denoted as Resolvins of the E series ( Resolvin E1 or RvE1 ) , and those biosynthesized from the precursor docosahexaenoic acid are Resolvins of the D series ( Resolvin D1 or RvD1 ) .
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