Corpus ID: 211068881

Resolving the degree of order in the bacterial chromosome using a statistical physics approach

  title={Resolving the degree of order in the bacterial chromosome using a statistical physics approach},
  author={J. Messelink and Jacqueline Janssen and Muriel C. F. van Teeseling and M. Thanbichler and C. Broedersz},
  journal={arXiv: Biological Physics},
While bacterial chromosomes were long thought to be amorphous, recent experiments reveal pronounced organizational features. However, the extent of bacterial chromosome organization remains unclear. Here, we develop a fully data-driven maximum entropy approach to extract the distribution of single-cell chromosome conformations from experimental normalized Hi-C data. We apply this inference to the model organism Caulobacter crescentus. On small genomic scales of 104-105 basepairs, our model… Expand

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