Corpus ID: 211068881

Resolving the degree of order in the bacterial chromosome using a statistical physics approach

@article{Messelink2020ResolvingTD,
  title={Resolving the degree of order in the bacterial chromosome using a statistical physics approach},
  author={J. Messelink and Jacqueline Janssen and Muriel C. F. van Teeseling and M. Thanbichler and C. Broedersz},
  journal={arXiv: Biological Physics},
  year={2020}
}
While bacterial chromosomes were long thought to be amorphous, recent experiments reveal pronounced organizational features. However, the extent of bacterial chromosome organization remains unclear. Here, we develop a fully data-driven maximum entropy approach to extract the distribution of single-cell chromosome conformations from experimental normalized Hi-C data. We apply this inference to the model organism Caulobacter crescentus. On small genomic scales of 104-105 basepairs, our model… Expand

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References

SHOWING 1-10 OF 14 REFERENCES
The three-dimensional architecture of a bacterial genome and its alteration by genetic perturbation.
  • 180
  • PDF
High-resolution 3D models of Caulobacter crescentus chromosome reveal genome structural variability and organization
  • 17
  • PDF
Rapid and sequential movement of individual chromosomal loci to specific subcellular locations during bacterial DNA replication.
  • 404
  • PDF
Spatial and temporal organization of replicating Escherichia coli chromosomes
  • 384
Positional information, in bits
  • 116
  • PDF
Genetics of Caulobacter crescentus.
  • B. Ely
  • Biology, Medicine
  • Methods in enzymology
  • 1991
  • 408
Molecular organization of Gram-negative peptidoglycan
  • 230
  • PDF
Proteolysis of the Caulobacter McpA chemoreceptor is cell cycle regulated by a ClpX-dependent pathway.
  • 74
  • Highly Influential
  • PDF
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