Resolving self-association of a therapeutic antibody by formulation optimization and molecular approaches.

@article{Casaz2014ResolvingSO,
  title={Resolving self-association of a therapeutic antibody by formulation optimization and molecular approaches.},
  author={Paul L Casaz and Elisabeth N. Boucher and Rachel B Wollacott and Brian G. Pierce and Rachel B. Rivera and Maja Sedic and Sadettin S. Ozturk and William Donald Thomas and Yang Wang},
  journal={mAbs},
  year={2014},
  volume={6 6},
  pages={
          1533-9
        }
}
A common challenge encountered during development of high concentration monoclonal antibody formulations is preventing self-association. Depending on the antibody and its formulation, self-association can be seen as aggregation, precipitation, opalescence or phase separation. Here we report on an unusual manifestation of self-association, formation of a semi-solid gel or "gelation." Therapeutic monoclonal antibody C4 was isolated from human B cells based on its strong potency in neutralizing… CONTINUE READING
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