Resolving nonstop translation complexes is a matter of life or death.

@article{Keiler2014ResolvingNT,
  title={Resolving nonstop translation complexes is a matter of life or death.},
  author={K. Keiler and Heather A. Feaga},
  journal={Journal of bacteriology},
  year={2014},
  volume={196 12},
  pages={
          2123-30
        }
}
Problems during gene expression can result in a ribosome that has translated to the 3' end of an mRNA without terminating at a stop codon, forming a nonstop translation complex. The nonstop translation complex contains a ribosome with the mRNA and peptidyl-tRNA engaged, but because there is no codon in the A site, the ribosome cannot elongate or terminate the nascent chain. Recent work has illuminated the importance of resolving these nonstop complexes in bacteria. Transfer-messenger RNA (tmRNA… Expand
44 Citations
Release of Nonstop Ribosomes Is Essential
  • 27
  • PDF
A new mechanism for ribosome rescue can recruit RF1 or RF2 to non-stop ribosomes
  • 1
  • PDF
Structural Basis for Ribosome Rescue in Bacteria.
  • 31
Mechanism of ribosome rescue by alternative ribosome-rescue factor B
  • 5
  • PDF
Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
  • 19
  • PDF
Mechanisms of ribosome rescue in bacteria
  • K. Keiler
  • Biology, Medicine
  • Nature Reviews Microbiology
  • 2015
  • 116
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 95 REFERENCES
tmRNA Is Essential in Shigella flexneri
  • 27
  • PDF
Lon protease degrades transfer-messenger RNA-tagged proteins.
  • 95
  • PDF
tmRNA regulates synthesis of the ArfA ribosome rescue factor
  • 73
Proteobacterial ArfA Peptides Are Synthesized from Non-stop Messenger RNAs*
  • 38
  • PDF
...
1
2
3
4
5
...