# Resolving molecular contributions of ion channel noise to interspike interval variability through stochastic shielding

@article{Pu2020ResolvingMC, title={Resolving molecular contributions of ion channel noise to interspike interval variability through stochastic shielding}, author={Shusen Pu and Peter J. Thomas}, journal={Biological Cybernetics}, year={2020}, volume={115}, pages={267 - 302} }

Molecular fluctuations can lead to macroscopically observable effects. The random gating of ion channels in the membrane of a nerve cell provides an important example. The contributions of independent noise sources to the variability of action potential timing have not previously been studied at the level of molecular transitions within a conductance-based model ion-state graph. Here we study a stochastic Langevin model for the Hodgkin–Huxley (HH) system based on a detailed representation of…

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