Resolving conflicting data on expression of the Tn antigen and implications for clinical trials with cancer vaccines.

@article{Li2009ResolvingCD,
  title={Resolving conflicting data on expression of the Tn antigen and implications for clinical trials with cancer vaccines.},
  author={Qian Li and Miriam Anver and Donna O. Butcher and Jeffrey C Gildersleeve},
  journal={Molecular cancer therapeutics},
  year={2009},
  volume={8 4},
  pages={
          971-9
        }
}
The tumor-associated Tn antigen has been investigated extensively as a biomarker and therapeutic target. Cancer vaccines containing the Tn antigen as a single tumor antigen or as a component of a polyvalent vaccine have progressed into phase I and II clinical trials. One major focus of Tn-based vaccines is the treatment of prostate cancer patients. Although expression of the antigen on prostate tumors is a critical prerequisite, previous reports investigating Tn expression in prostate tumors… CONTINUE READING

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