Resolving T-cell receptor clonality in two and genotype in four multiplex polymerase chain reactions.

@article{Dictor2005ResolvingTR,
  title={Resolving T-cell receptor clonality in two and genotype in four multiplex polymerase chain reactions.},
  author={Michael Dictor and Janina Warenholt and Anna P Isinger},
  journal={Haematologica},
  year={2005},
  volume={90 11},
  pages={1524-32}
}
BACKGROUND AND OBJECTIVES The diagnosis of T-cell neoplasia requires the use of immunohistochemistry on tumor sections or molecular genetic analysis of T-cell receptor (TCR) clonality. Multiplex polymerase chain reactions (PCR) offer a sensitive and expeditious approach to determining clonality early in the diagnostic work-up. We determined the sensitivity and specificity of four multiple PCR for genotyping lymphoid neoplasms at the TCR loci gamma (TCRG), delta (TCRD) and beta (TCRB, including… CONTINUE READING