Resolvin E1 and chemokine-like receptor 1 mediate bone preservation.

@article{Gao2013ResolvinEA,
  title={Resolvin E1 and chemokine-like receptor 1 mediate bone preservation.},
  author={Li Hong Gao and Dan Faibish and Gabrielle Fredman and Bruno Schneider Herrera and Nan Chiang and Charles Nicholas Serhan and Thomas E Van Dyke and Robert Gyurko},
  journal={Journal of immunology},
  year={2013},
  volume={190 2},
  pages={
          689-94
        }
}
The polyunsaturated ω-3 fatty acid eicosapentaenoic acid-derived resolvin E1 (RvE1) enhances resolution of inflammation, prevents bone loss, and induces bone regeneration. Although the inflammation-resolving actions of RvE1 are characterized, the molecular mechanism of its bone-protective actions are of interest. To test the hypothesis that receptor-mediated events impact bone changes, we prepared transgenic mice overexpressing the RvE1 receptor chemokine-like receptor 1 (chemR23) on leukocytes… CONTINUE READING
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