Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

  title={Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis},
  author={Matthew R. Spite and Lucy V Norling and L. A. Summers and Rong Yang and Dianne Cooper and Nicos A Petasis and Roderick John Flower and Mauro Perretti and Charles N Serhan},
A growing body of evidence indicates that resolution of acute inflammation is an active process. Resolvins are a new family of lipid mediators enzymatically generated within resolution networks that possess unique and specific functions to orchestrate catabasis, the phase in which disease declines. Resolvin D2 (RvD2) was originally identified in resolving exudates, yet its individual contribution in resolution remained to be elucidated. Here, we establish RvD2’s potent stereoselective actions… CONTINUE READING
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