Resolvin D1 protects mice from LPS-induced acute lung injury.

  title={Resolvin D1 protects mice from LPS-induced acute lung injury.},
  author={Bin Wang and Xia Gong and Jing-yuan Wan and Li Zhang and Zhuo Zhang and Hong-zhong Li and Su Min},
  journal={Pulmonary pharmacology & therapeutics},
  volume={24 4},
Resolvin D1 (RvD1), an endogenous lipid molecule derived from docosahexaenoic acid (DHA), has been described to promote inflammatory resolution. The present study aimed to determine the protective effects and the underlying mechanisms of RvD1 on lipopolysaccharide (LPS)-induced acute lung injury (ALI). Pretreatment RvD1 to mice 30 min before inducing ALI by LPS decreased the mortality and improved lung pathological changes, inhibited LPS-induced increases in polymorphonulear and mononuclear… CONTINUE READING


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