Resolvin D1 binds human phagocytes with evidence for proresolving receptors.

@article{Krishnamoorthy2010ResolvinDB,
  title={Resolvin D1 binds human phagocytes with evidence for proresolving receptors.},
  author={Sriram Krishnamoorthy and Antonio Recchiuti and Nan Chiang and Stephanie Yacoubian and C. H. Lee and Rong Yang and Nicos A Petasis and Charles Nicholas Serhan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 4},
  pages={
          1660-5
        }
}
Endogenous mechanisms that act in the resolution of acute inflammation are essential for host defense and the return to homeostasis. Resolvin D1 (RvD1), biosynthesized during resolution, displays potent and stereoselective anti-inflammatory actions, such as limiting neutrophil infiltration and proresolving actions. Here, we demonstrate that RvD1 actions on human polymorphonuclear leukocytes (PMNs) are pertussis toxin sensitive, decrease actin polymerization, and block LTB(4)-regulated adhesion… CONTINUE READING

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