Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways.

@article{Serhan2007ResolutionPO,
  title={Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways.},
  author={Charles N Serhan},
  journal={Annual review of immunology},
  year={2007},
  volume={25},
  pages={101-37}
}
Resolution of inflammation and the return of tissues to homeostasis are essential. Efforts to identify molecular events governing termination of self-limited inflammation uncovered pathways in resolving exudates that actively generate, from essential omega fatty acids, new families of local-acting mediators. These chemical mediator families, termed resolvins and protectins, are potent stereoselective agonists that control the duration and magnitude of inflammation, joining the lipoxins as… CONTINUE READING
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