Resolution of vaccinia virus DNA concatemer junctions requires late-gene expression.

@article{Merchlinsky1989ResolutionOV,
  title={Resolution of vaccinia virus DNA concatemer junctions requires late-gene expression.},
  author={Michael J Merchlinsky and Bernard Moss},
  journal={Journal of virology},
  year={1989},
  volume={63 4},
  pages={1595-603}
}
Vaccinia virus replicates in the cytoplasm of infected cells, generating transient replicative intermediates containing the DNA for the terminal sequences as concatemeric junctions. The processing of the terminal sequences for a series of vaccinia virus conditional lethal mutants at the nonpermissive temperature was analyzed by restriction enzyme digestion and Southern blot hybridization of DNA isolated from infected cells. Three phenotypes were observed: DNA replication negative (Rep-), DNA… CONTINUE READING
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