Resolution of vaccinia virus DNA concatemer junctions requires late-gene expression.

  title={Resolution of vaccinia virus DNA concatemer junctions requires late-gene expression.},
  author={Michael J Merchlinsky and Bernard Moss},
  journal={Journal of virology},
  volume={63 4},
Vaccinia virus replicates in the cytoplasm of infected cells, generating transient replicative intermediates containing the DNA for the terminal sequences as concatemeric junctions. The processing of the terminal sequences for a series of vaccinia virus conditional lethal mutants at the nonpermissive temperature was analyzed by restriction enzyme digestion and Southern blot hybridization of DNA isolated from infected cells. Three phenotypes were observed: DNA replication negative (Rep-), DNA… CONTINUE READING
Highly Cited
This paper has 75 citations. REVIEW CITATIONS
19 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 19 extracted citations

76 Citations

Citations per Year
Semantic Scholar estimates that this publication has 76 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…