Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation.

@article{Allman2001ResolutionOT,
  title={Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation.},
  author={David M. Allman and R Coleman Lindsley and W Demuth and Kristina Rudd and Susan A Shinton and Richard R Hardy},
  journal={Journal of immunology},
  year={2001},
  volume={167 12},
  pages={6834-40}
}
Although immature/transitional peripheral B cells may remain susceptible to selection pressures before full maturation, the nature and timing of these selection events remain unclear. We show that correlated expression of surface (s) IgM (sIgM), CD23, and AA4 defines three nonproliferative subpopulations of immature/transitional peripheral B cells. We designate these populations transitional (T) 1 (AA4(+)CD23(-)sIgM(high)), T2 (AA4(+)CD23(+)sIgM(high)), and T3 (AA4(+)CD23(+)sIgM(low)). Cells… CONTINUE READING
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