Resolution of primary amyloidosis during chemotherapy. Studies in a patient with nephrotic syndrome.

@article{Cohen1975ResolutionOP,
  title={Resolution of primary amyloidosis during chemotherapy. Studies in a patient with nephrotic syndrome.},
  author={Harvey Jay Cohen and Lawrence S. Lessin and J C Hallal and Peter M. Burkholder},
  journal={Annals of internal medicine},
  year={1975},
  volume={82 4},
  pages={466-73}
}
A patient with primary amyloidosis with evidence for a plasma cell dyscrasia but no abnormal immunoglobulin components had nephrotic syndrome with severe renal impairment. Kidney and bone marrow had extensive amyloid infiltration. She was treated with penicillamine, malphalan, prednisone, and fluoxymesterone; through 6 months renal function gradually improved; urine protein excretion dropped dramatically, serum albumin rose; liver size decreased; the bone marrow returned towards normal. During… CONTINUE READING

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