Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine

@inproceedings{Cunniff2014ResolutionOO,
  title={Resolution of oxidative stress by thioredoxin reductase: Cysteine versus selenocysteine},
  author={Brian Cunniff and Gregg W. Snider and Nicholas Fredette and Jason Stumpff and Robert J Hondal and Nicholas H. Heintz},
  booktitle={Redox biology},
  year={2014}
}
Thioredoxin reductase (TR) catalyzes the reduction of thioredoxin (TRX), which in turn reduces mammalian typical 2-Cys peroxiredoxins (PRXs 1-4), thiol peroxidases implicated in redox homeostasis and cell signaling. Typical 2-Cys PRXs are inactivated by hyperoxidation of the peroxidatic cysteine to cysteine-sulfinic acid, and regenerated in a two-step… CONTINUE READING