Resolution of neurotoxicity and beta-cell toxicity in an islet transplant recipient following substitution of tacrolimus with MMF.

@article{Froud2006ResolutionON,
  title={Resolution of neurotoxicity and beta-cell toxicity in an islet transplant recipient following substitution of tacrolimus with MMF.},
  author={Tatiana Froud and David A. Baidal and Gaston G Ponte and Jacqueline V Ferreira and Camillo Ricordi and Rodolfo Alejandro},
  journal={Cell transplantation},
  year={2006},
  volume={15 7},
  pages={613-20}
}
Calcineurin inhibitors such as tacrolimus have well-recognized efficacy in organ transplantation but side effects of nephrotoxicity, neurotoxicity, and beta-cell toxicity that can be particularly detrimental in islet transplantation. Neuro- and nephrotoxicity have been demonstrated in multiple islet transplant recipients despite the relatively low serum maintenance levels typically used (3-5 ng/ml). We describe a single patient in whom symptoms and signs of neurotoxicity necessitated… CONTINUE READING
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